Oral leukoplakia
Conditions
Interventions
Experimental Group:Laser pretreatment
Sponsors
Peking University School of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1 Age: 18-75 years old, gender not limited, Han Chinese. 2 Meet the diagnostic criteria for oral leukoplakia (OLK) : 3 Lesions that occur on the oral mucosa and are mainly white cannot be wiped off, nor can they be clinically or histologically observed Pathological methods diagnose it as other definable lesions, which fall within the category of precancerous lesions or potential malignant disorders This does not include oral leukokeratosis that can subside after the removal of factors such as smoking and local friction. 4 To ensure the consistency of treatment, the maximum diameter of the lesion should not exceed 4cm. Only homogeneous leukoplakia and verrucous leukoplakia were included Spots and granular white patches.
Exclusion criteria
Exclusion criteria: 1 Pregnant women, lactating women, and women of childbearing age with pregnancy plans within one year. 2 Accompanied by other oral mucosal disorders 3 Accompanied by severe acute infectious diseases throughout the body; Uncontrolled systemic diseases (coagulation disorders, autoimmune diseases, diabetes, cardiovascular diseases, mental illnesses, etc. Suffering from malignancy in other parts of the body. 4 Those who have received surgical treatment or radiotherapy and chemotherapy for potential malignant oral diseases or head and neck tumors in the past patient. 5 People who are allergic to light within a wavelength range of approximately 630±5nm. 6 Those who are allergic to any component in the topical solution of aminovaleric hydrochloride. 7 People who are allergic to local anesthetic drugs. 8 People allergic to porphyrins. 9 Any patient who is unwilling or unable to receive this treatment for any other reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical effectiveness;Treatment time per unit area of lesion;VAS ;Course of treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Toluidine blue staining;Autofluorescence examination;DNA polyploid examination of exfoliated cells; | — |
Countries
China
Contacts
Public ContactYing Han
Peking University School of Stomatology
Outcome results
None listed