The Clinical Efficacy of Esketamine on General Anesthesia Induction and Its Impact on Postoperative Cognition and Mood

The Clinical Efficacy of Esketamine on General Anesthesia Induction in Elderly Patients with Trigeminal Neuralgia and Its Impact on Postoperative Cognition and Mood

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500106032

Enrollment

Unknown

Registered

2025-07-16

Start date

2025-03-21

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Trigeminal Neuralgia

Interventions

The control group:blank control

Esketamine group:esketamine

Eligibility

Sex/Gender

All

Age

65 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. American Society of Anesthesiologists (ASA) physical status II or III; 2. aged between 65 and 80 years, 3. diagnosed with primary trigeminal neuralgia, and not taking any medications that affect the function of the autonomic nervous system.

Exclusion criteria

Exclusion criteria: 1. Secondary trigeminal neuralgia; 2. Severe hypertension; 3. Diabetes mellitus; 4. Severe cardiopulmonary dysfunction; 5. Arrhythmia; 6. Patients with pacemakers or other implanted cardiac devices; 7. Participation in other clinical studies; 8. Inability to communicate or cooperate; 9. Refusal to participate.

Design outcomes

Primary

Measure	Time frame
Depressive symptoms;	—

Secondary

Measure	Time frame
Cognitive Function;Postoperative adverse reactions;the frequency of vasoactive drug use;SpO2;heart rate;mean arterial pressure;	—

Countries

China

Contacts

Public ContactFang Xinhua

Jiangxi Provincial People's Hospital

xinhua9251@163.com+86 187 2099 7901

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026