Sex differences in heart rate variability, postoperative nausea and vomiting
Conditions
Interventions
High-dose sufentanil group (experimental group):0.5ug/kg sufentanil pushed at induction of anesthesia
Low-dose sufentanil group (control group):0.3ug/kg sufentanil pushed at induction of anesthesia
Sponsors
Qilu Hospital, Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with thyroid cancer; 2. Age 18-65 years old; 3.BMI:18-35kg/m^2; 4. American Society of Anesthesiologists (ASA) class I.-III; 5. Patients who intend to undergo radical thyroidectomy under general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Those who have smoked, drunk, drunk coffee or had poor sleep recently; 2. Recent opioid users; 3. Those with severe respiratory diseases; 4. Patients with serious neurological and psychiatric diseases; 5. Those with diseases that affect autonomic nerve function and are poorly controlled; 6. Severe cardiopulmonary cerebrovascular or liver and kidney function impairment; 7. Mood disorders such as anxiety and depression before surgery; 8. Taking drugs that affect HRV (such as ß receptor blockers, antiarrhythmics, antidepressants, etc.); 9. Do not agree to participate in this study; 10. Other reasons why the investigator thinks it is not appropriate to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall incidence of PONV at 24h postoperatively;Mean values of LF/HF and RMSSD between the start of anesthesia induction and the end of surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of PONV in the immediate postoperative period, 0-6h, 6-24h;Use of remedial antiemetics in the 24h postoperative period;Visual analog scores of patient pain in the immediate, 6h, and 24h postoperative periods;Use of remedial analgesics in the 24h postoperative period;Hemodynamic parameters, including heart rate, diastolic and systolic blood pressure, and EEG bifrequency indices, at different points in time during the operation;Values of heart rate variability parameters such as low-frequency power (LF), high-frequency power (HF), low-frequency/high-frequency ratio (LF/HF), normalized high-frequency (HFnu), total power (TP), SDNN (standard deviation of normal RR intervals), and RMSSD (root-mean-square of the difference between adjacent RR intervals) at each time point;Intraoperative use of cardiovascular active drugs;Time of awakening;Time of extubation;Incidence of intraoperative hypertension, hypotension, bradycardia, tachycardia, and postoperative respiratory depression, chills, and other adverse effects in patients; | — |
Countries
China
Contacts
Public ContactFeng Qi
Qilu Hospital, Shandong University
Outcome results
None listed