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Research on the Efficacy of Transcranial Magnetic Stimulation Targeting Different Sites Based on Neurophysiological Exploration in Patients with Disorders of Consciousness After Brain Injury

Research on the Efficacy of Transcranial Magnetic Stimulation Targeting Different Sites Based on Neurophysiological Exploration in Patients with Disorders of Consciousness After Brain Injury

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500106020
Enrollment
Unknown
Registered
2025-07-16
Start date
2024-04-11
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain injury

Interventions

Observation Group 1:The EEG site corresponding to the left DLPFC is F3, and the treatment involves transcranial magnetic stimulation.
Observation Group 2:The EEG site corresponding to the cortical motor area is C3, and the treatment involves transcranial magnetic stimulation.
Observation Group 3:The EEG site corresponding to the parietal lobe is P3, and the treatment involves transcranial magnetic stimulation.
Control Group:Sham stimulation treatment.

Sponsors

Quzhou People’s Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1.Confirmed diagnosis of traumatic brain injury (intracranial hemorrhage, cerebral infarction, traumatic brain injury, and hypoxic encephalopathy) with associated disorders of consciousness, and a Glasgow Coma Scale (GCS) score <= 9; 2.Early rehabilitation initiated within 2-12 weeks after the onset of brain injury; 3.Age between 18 and 60 years; 4.This is the first episode of brain injury; 5.Stable vital signs and no other severe medical conditions.

Exclusion criteria

Exclusion criteria: 1.History of seizures within the past month; 2.Individuals with contraindications for transcranial magnetic stimulation, such as having metal foreign bodies inside the body or other implanted electronic devices; 3.Skull defect.

Design outcomes

Primary

MeasureTime frame
The coma recoveryscale revised score, CRS-R;EEG indicators;Short latency somatosensory evoked potentials,SLSEP;Brainstem auditory evoked potential,BAEP;

Countries

China

Contacts

Public ContactJian Xu

The Quzhou Affiliated Hospital of Wenzhou Medical University

doctorxu2009@126.com+86 151 5877 4235

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026