Psychiatry and Mental Health
Conditions
Interventions
Sponsors
West China School of Medicine/West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Conform to The diagnostic criteria for depression in The diagnostic and statistical manual of mental disorders-5 (DSM-5); 2. Male or female, outpatients or inpatients; 3. Han ethnicity; 4. Age over 18 years old and under 65 years old; 5. Patients who sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women who are unwilling to take contraceptive measures during the study period; 2. Patients who are allergic to buspirone or have one of the contraindications for buspirone; 3. Patients who suffer from severe or unstable diseases and are judged by the researchers as unsuitable to participate in this study; 4. Patients with a history of any neurological diseases (including epileptic seizures, brain injury, multiple sclerosis, degenerative diseases such as acute lateral sclerosis, Parkinson's disease and movement disorders, etc.); 5. Those diagnosed with other mental disorders; 6. Those who have regularly used buspirone or tandospirone, antipsychotic drugs, mood stabilizers, antiepileptic drugs or have used long-acting preparations within two weeks; 7. Those who are treated with two or more antidepressant drugs; 8. Patients who are currently undergoing or have received ECT treatment within the past six months; 9. Professional drivers or patients engaged in dangerous mechanical operations; 10. Patients who have participated in other clinical studies and taken drugs provided by the sponsor within the last 3 months; 11. Patients with clinically significant electrocardiogram or laboratory test abnormalities; Patients with acute angle-closure glaucoma; 13. Patients with myasthenia gravis; 14. Those with serious suicidal attempts; 15. Or those with severe impulses.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression;Anxiety;Clinical efficacy;Neurocognitive function; | — |
Countries
China
Contacts
Public ContactXiaohong Ma
West china hospital, Sichuan University
Outcome results
None listed