Postoperative delirium
Conditions
Interventions
Experimental group:The induction dose of remimazolam tosilate was age-stratified: 0.25 mg/kg for patients aged 65-74 years and 0.2 mg/kg for those >75 years. The maintenance dose was 0.3-0.5 mg/kg/h.
Control group:Propofol was administered at 0.15 mg/kg for induction and maintained at 2-4 mg/kg/h.
Sponsors
The Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective surgery, aged >= 65 years; 2. Participating in medium to large-scale general anesthesia surgeries (gastrointestinal, hepatobiliary, orthopedic), with an estimated surgical duration of >= 2 hours; 3. ASA grade I–III.
Exclusion criteria
Exclusion criteria: 1.Inability to complete the neurocognitive assessment due to language, visual, or auditory impairments; 2. Obvious dementia (Mini-Mental State Examination [MMSE] score <24); 3. History of cerebrovascular disease, intracranial disease, or psychiatric illness, or regular use of benzodiazepines; 4. Undergoing cardiac or cranial surgery; 5. Expected postoperative hospital stay of less than 5 days; 6. Unwillingness to participate in postoperative assessments and sampling; 7. Preoperative MMSE score below the normal range; 8. Presence of delirium before surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium within 3 days after surgery;The incidence of postoperative delirium requiring pharmacological treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time from the end of surgery to extubation; | — |
Countries
China
Contacts
Public ContactZhong Yi
The Affiliated Hospital of Guizhou Medical University
Outcome results
None listed