Esophageal Cancer
Conditions
Sponsors
Department of Anesthesiology, Affiliated Cancer Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients undergoing radical resection of esophageal cancer under cervical and abdominal thoracoscopy under intravenous anesthesia at the elective stage 2. Age>=65 years 3.BMI18.5~28kg/m^2 4. ASAII.~III
Exclusion criteria
Exclusion criteria: 1. Long-term use of psychotropic drugs or sedative analgesics before surgery. 2. History of allergy to any of the drugs used in this study. 3. Cognitive dysfunction before surgery (positive score on the preoperative 3D-CAM assessment). 4. History of brain diseases or head trauma. 5. Severe preoperative liver or kidney dysfunction or severe cardiac insufficiency (NYHA Class IV). 6. History of other cancer treatments. 7. Participation in other studies within the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The average intraoperative dose of remifentanil; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative delirium;Intraoperative opioid dosage (converted to morphine equivalent);Total postoperative opioid consumption (converted to morphine equivalents);Visual analogue scale (VAS) pain scores at rest and during activity on postoperative days 1, 2, and 3.;Use of rescue analgesics and pain medications by patients on postoperative days 1, 2, and 3.;Postoperative hospital stay duration;The number of effective presses and the total number of presses on the patient-controlled intravenous analgesia (PCIA) pump postoperatively.; | — |
Countries
China
Contacts
Public ContactZhang Minhao
Department of Anesthesiology, Affiliated Cancer Hospital of Nanjing Medical University
Outcome results
None listed