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A Randomized, Controlled, Single-Center Clinical Trial Investigating the Efficacy and Safety of Physical Rehabilitation Therapy on Functional Recovery in Patients Following Anterior Cruciate Ligament Reconstruction

A Randomized, Controlled, Single-Center Clinical Trial Investigating the Efficacy and Safety of Physical Rehabilitation Therapy on Functional Recovery in Patients Following Anterior Cruciate Ligament Reconstruction

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500105951
Enrollment
Unknown
Registered
2025-07-15
Start date
2025-07-30
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee anterior cruciate ligamnet injuries

Interventions

Repetitive transcranial magnetic stimulation group:Stimulation is delivered to the primary motor cortex (M1) of the affected hemisphere using the following parameters: a frequency of 10 Hz administer
Blood flow restriction training group:Conventional rehabilitation training is combined with Blood Flow Restriction (BFR) training. Conventional rehabilitation includes knee flexion/extension exercises
Transcranial direct current stimulation group:Transcutaneous Direct Current Stimulation is combined with quadriceps training. Participants assume a supine position. The center of the cathode electrod

Sponsors

First Affiliated Hospital of Army Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Patients within 1 month after the first unilateral anterior cruciate ligament reconstruction; 2. There is no restriction on the type of reconstructed graft, with or without meniscus injury or surgery; 3. Age 18-45 years old, male or female; 4. Absence of diseases affecting activity level such as brain, heart, and lungs; 5. Participation in this study is completely voluntary.

Exclusion criteria

Exclusion criteria: 1. Patients with concurrent severe lower extremity injuries, such as rupture of the collateral ligament of the knee, fractures, Achilles tendon tears, etc; 2. Patients with a history of anterior cruciate ligament or posterior cruciate ligament reconstruction; 3. Patients with severe diseases of the cardiovascular and cerebrovascular system, liver and kidney, hematopoietic system, nervous system, lumbar spine, etc; 4. Patients with contraindications to electrical stimulation, such as pacemakers, pregnancy, epilepsy, etc; 5. Patients and their families with poor compliance who refuse to complete the treatment; Note: Any patient who meets any of the above criteria should be excluded.

Design outcomes

Primary

MeasureTime frame
Knee injury and Osteoarthritis Outcome Score, KOOS;—

Secondary

MeasureTime frame
Range of Motion, ROM;Victoria Institute of Sports Assessment Score, VISA;Anterior Cruciate Ligament - Quality of Life, ACL- QoL;Tegner Activity Level Scale;Gait parameters;Lysholm Knee Score;Surface electromyography parameters;Tampa Scale for Kinesiophobia, TSK;Motor threshold;Balance and Proprioception;Single Leg Hop Test;Dynamic digital radiography parameters;7-Tesla Magnetic Resonance Imaging of the Knee Joint parameters;7-Tesla Functional Magnetic Resonance Neuroimaging parameters;Muscle Strength Testing;—

Countries

China

Contacts

Public ContactGuo Lin

First Affiliated Hospital of Army Medical University

guolin6212@163.com+86 199 3817 7463

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026