Alzheimer's Disease
Conditions
Interventions
Test group:Take 1 capsule of Faecalibacterium prausnitzii every morning on an empty stomach for a total of 28 weeks.
Control group:Take 1 placebo capsule every morning for a total of 28 weeks.
Sponsors
Chaohu Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for AD in DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, 5th edition); 2. aged 55-80 years; 3. being able to understand the instructions and cooperate in completing the scale assessment; 4. having family members who can sign the informed consent form on behalf of the patient.
Exclusion criteria
Exclusion criteria: 1.having other central nervous system diseases that may cause cognitive impairment, such as stroke, temporal lobe dementia, Parkinson's disease, epilepsy, tumor, encephalitis, etc.; 2.having a history of mental illness that meets the diagnostic criteria in Diagnostic and Statistical Manual of Mental Disorders (DSM-5); 3.cognitive impairment occurring after craniocerebral trauma; 4.having a history of drug abuse, alcohol dependence, poisoning, or exposure to harmful substances such as radiation; 5.having unstable or severe diseases of the heart, lungs, liver, kidneys, or hematopoietic system, poor physical condition, or having major diseases with a very short life expectancy; 6.currently participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in cognitive function and quality of life; | — |
Secondary
| Measure | Time frame |
|---|---|
| ECG, blood routine, blood biochemical test ;types and quantities of gut microbes; | — |
Countries
China
Contacts
Public ContactZhang Kai
Chaohu Hospital of Anhui Medical University
Outcome results
None listed