Infectious thoracic diseases
Conditions
Interventions
PVA :Receive PVA particle embolization combined with surgical operation of the internal artery
embolic microspheres :Receive embolic microspheres embolization combined with surgical operation of the internal artery
PVA +embolic microspheres :Receive PVA particle and embolic microspheres embolization combined with surgical operation of the internal artery
Sponsors
Shanghai Pulmonary Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Laboratory and imaging examinations have confirmed the diagnosis of chest infectious diseases, including tuberculous destructive lung, chronic empyema, pulmonary fungal infection, chronic lung abscess, and bronchiectasis with infection, etc. 2.Patients with thoracic infectious diseases: Tuberculous destructive lung lesions involving a single or multiple lung lobes, chronic empyema, pulmonary fungal infection, chronic lung abscess, and bronchiectasis with infection. Two senior chest imaging physicians completed the diagnosis blindly. In case of disagreement, the third senior chest imaging physician made the final decision. 3.Patients who can undergo surgical treatment including lobectomy, combined lobectomy or pneumonectomy, as well as empyema pleurodesis surgery for treatment 4.Age: >= 18 years old, = 1.5 x 10^9/L, platelets>= 100 x 10^9/L, hemoglobin >= 90 g/L. International normalized ratio (INR) or prothrombin time (PT) =3 months. 9.informed consent obtained, with good compliance and willingness to cooperate with follow-up.
Exclusion criteria
Exclusion criteria: 1. Patients with combined malignant tumors; 2. Those who have had a history of thoracic surgery in the past; 3. Those who have not received standard anti-infection treatment (including anti-tuberculosis, aspergillus, etc.); 4. Patients with major diseases involving the heart, kidneys, liver, bone marrow or central nervous system; 5. Patients with uncontrollable asthma, heart failure, idiopathic pulmonary fibrosis, etc.; 6. Pregnant or lactating women; 7. Patients judged by the researcher to be unsuitable for SSAE due to clinical conditions ( for arterial puncture); 8. Uncontrollable hyperthyroidism; 9. Those who are severely allergic to iodine contrast agents; 10. Patients whose condition, as judged by the researcher, poses a serious threat to patient safety or affects their ability to complete the study; 11. Patients currently participating in or participating in other clinical trials within 4 weeks before the surgery. twelve Patients with mental disorders or a history of abuse of psychotropic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bleeding volume during operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Surgical operation time;Separation time of pleural adhesions;The situation of conversion to thoracotomy during total thoracoscopic surgery;Postoperative thoracic drainage volume, time of thoracic tube extraction, and pulmonary leakage;The incidence of bleeding events within one week and one month after the operation;The infection rate occurred during the perioperative period;Pulmonary function before and after the operation; | — |
Countries
China
Contacts
Public ContactSen Jiang
Shanghai Pulmonary Hospital
Outcome results
None listed