None listed
Conditions
Interventions
Esketamine group:Intravenous injection of 0.5mg/kg (i.v., anesthesia induction period), 0.25mg/kg (i.v., 10 minutes before the end of surgery)
Control group:Intravenous injection of equal volume physiological saline
Sponsors
The Second Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age: 18 to 65 years old; (2) ASA:I-III; (3) Preoperative Pittsburgh Sleep Quality Index (PSQI) score >= 9 points; (4) Abdominal surgery under general anesthesia, with a duration of >= 2 hours; (5) Voluntary acceptance of postoperative patient-controlled intravenous analgesia (PCIA); (6) Agree to participate in this trial, and sign an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Chronic pain before surgery or current use of painkillers; (2) Patients allergic to ketamine or with contraindications like grade 3 hypertension, hyperthyroidism, or severe heart disease; (3) Severe liver and kidney dysfunction; (4) Cognitive impairment or inability to communicate; (5) Refusal to use PCIA or refuse to participate in this trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| sleep quality assessment; | — |
Countries
China
Contacts
Public ContactDuan Guanyou
The Second Affiliated Hospital of Chongqing Medical University
Outcome results
None listed