Breast cancer
Conditions
Interventions
Experimental group (Group E) :In Group E, 0.25mg/kg of esketamine was slowly intravenously injected 5min before induction, and 0.1mg/kg/h of esketamine was continuously pumped during operation until t
Control group (group n):The same amount of normal saline was infused intravenously in group n.
Sponsors
The First Affiliated Hospital of Bengbu Medical College
Eligibility
Sex/Gender
Female
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. American Society of anesthesiologists (ASA) grade ? - ? patients; 2. Patients aged 20-60 years; 3. Patients who choose to undergo breast cancer surgery under general anesthesia; 4. Patients with body mass index (BMI) of 18-28 kg/m2; 5. Patients who can independently complete the CES-D scale and score >=16 points; 6. Patients gave informed consent for this study.
Exclusion criteria
Exclusion criteria: 1. Patients with previous history of neurological and psychiatric diseases; 2. Patients taking psychotropic drugs in recent 3 months; 3. Patients with heart, liver, kidney and other organ dysfunction or patients with coagulation dysfunction; 4. Patients with a history of allergy to the active ingredients of the study drug; 5. Patients with contraindications to esketamine (arteriosclerosis, coronary heart disease, cardiac insufficiency, cor pulmonale, pulmonary hypertension, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Electroencephalogram; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Center for Epide-miological Studies Depression Scale;Self-rating Depression Scale;5-hydroxytryptamine;Usage of analgesic pump;Intraoperative anesthetic drug dosage; | — |
Countries
China
Contacts
Public ContactNanhai Wang
The First Affiliated Hospital of Bengbu Medical College
Outcome results
None listed