ENT surgery
Conditions
Interventions
EC50 group:The initial target controlled infusion concentration of remifentanil is 6.0 ng/mL, and according to the sequential method, it is preset to be adjusted in a gradient of 1 ng/mL. If the cardi
ED50 and ED95 group:The initial target controlled infusion concentration of remifentanil is 0.5 µ g/kg, and according to the sequential method, it is preset to be adjusted in a gradient of 0.1 µ g/kg.
Sponsors
Shandong Second Provincial General Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age range of 65-80 years old; (2) American Society of Anesthesiologists (ASA) grades I-III; (3) Elective ear, nose and throat surgery for treatment; (4) Plan to undergo general anesthesia; (5) Sign informed consent forms, conduct pain scoring education, and cooperate in data collection.
Exclusion criteria
Exclusion criteria: (1) Preoperative uncontrolled hypertension (SBP>180mmHg) or arrhythmia; (2) Assessment as difficult airway; (3) Poor control of hypertension and severe heart disease; (4)BMI>= 30 kg/m^2; (5) History of chronic pain or opioid use; (6) Has kidney, liver or blood dysfunction; (7) Currently taking beta blockers, analgesics, or psychotropic drugs; (8) There are contraindications for the use of remifentanil, (9) Any other reasons that prevent cooperation with the research, such as language comprehension barriers, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate;Mean arterial pressure;Depth of anesthesia; | — |
Countries
China
Contacts
Public ContactJuan Zhao
Shandong Second Provincial General Hospital
Outcome results
None listed