Chronic atrophic gastritis
Conditions
Interventions
Chronic atrophic gastritis group:The chronic atrophic gastritis group was treated with the YIQIHUAYUJIEDU formula. The formula consisted of: Astragalus membranaceus 30g, Codonopsis pilosula 15g, Atrac
Sponsors
Beijing University of Chinese Medicine Shenzhen Hospital (Longgang)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients who meet the diagnostic criteria for gastric precancerous diseases (confirmed by electronic gastroscopy and histopathological examination as atrophy, with or without intestinal metaplasia, with or without mild to moderate dysplasia) or the diagnostic criteria for CSG (chronic superficial gastritis), and are diagnosed with spleen deficiency syndrome in traditional Chinese medicine (TCM); 2. Age between 18 and 65 years; 3. No intake of relevant medications within one week; 4. Able to communicate normally and sign the informed consent form; Only those who meet all the above criteria can be included in the study.
Exclusion criteria
Exclusion criteria: (1) Patients with organic gastrointestinal diseases, including peptic ulcers, type A gastritis, gastrointestinal tumors, or gastrointestinal bleeding; (2) Patients with severe comorbidities affecting the heart, brain, kidneys, liver, or coagulation function; (3) Patients with a history of gastric surgery; (4) Patients unable to cooperate with biopsy collection; (5) Pregnant or lactating women, as well as individuals with severe mental illness who are unwilling to comply with the study. Patients meeting any of the above criteria were excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathological score of gastric mucosa;The results of gastric endoscopy examination;Transcriptomics of gastric mucosal tissue;Metagenomics of gastric mucosal tissue;The expression of p-JAK2 protein and JAK2 gene in gastric mucosal tissue;The expression of p-STAT3 protein and STAT3 gene in gastric mucosal tissue;The expression of P53 protein and genes in gastric mucosal tissue;The expression of P21 protein and genes in gastric mucosal tissue; | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver function;renal function; | — |
Countries
China
Contacts
Public ContactShuni Chen
Beijing University of Chinese Medicine Shenzhen Hospital (Longgang)
Outcome results
None listed