Knee Osteoarthritis
Conditions
Interventions
Experimental group:Intra-articular injection of hyaluronic acid and infrapatellar fat pad injection of triamcinolone acetonide
Control group1:Intra-articular injection of hyaluronic acid and infrapatellar fat pad injection of placebo
Control group2:Intra-articular injection of placebo and infrapatellar fat pad injection of triamcinolone acetonide
Sponsors
The First People's Hospital of Hefei
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Meet the American College of Rheumatology's clinical and radiographic criteria for diagnosing knee OA with knee pain (monthly pain >= 14 days prior to the start of the study, >= 3 months, 24-hour mean pain score (0-10) using the daily average of the pre-participation score) >= 4 points); 2. Patients with mild to moderate knee arthritis graded as grade 1, 2 and 3 according to KL; 3. Age greater than 40 years old; 4. Knee pain persisting for more than 6 months, and the pain (100 mm) assessed by VAS in the last week >= 40 mm; 5. MRI assessment of hoffa-synovitis score (MRI Osteoarthritis Knee score (MOAKS method) and effusion-synovitis score (MOAKS method) >=1, with a total score of >=3; 6. Body mass index (BMI) \u003C 40 kg/ m^2; 7. Knee stability, no knee deformity or lumbar spondylosis with radiculopathy; 8. Able to listen, speak, read and understand Chinese; Able to understand study requirements, collaborate with the investigators during the course of the study, and provide written informed consent.
Exclusion criteria
Exclusion criteria: Patients with the following diseases or symptoms: 1. Glucocorticoid or hyaluronic acid injections in the knee joint within the past 6 months; 2. Received invasive knee treatment within the past 6 months; 3. Planned hip or knee surgery (including arthroscopy, arthroplasty and other open joint surgeries) within the next 6 months; 4. Metabolic disease or anticoagulation therapy; 5. History of allergy to any of the study drugs; 6. Have inflammatory arthritis, autoimmune disease, septic arthritis, or any other concomitant disease (such as liver and kidney disease); 7. End-stage knee osteoarthritis (KL grade 4); 8. History of knee arthroplasty or infection of the affected limb; 9. Contraindications to MRI (e.g., implantable pacemakers, artificial metal valves or corneas, aneurysm clipping surgery, arterial dissection, intraocular metallic foreign bodies, claustrophobia); 10. Malignant tumors or other life-threatening diseases; 11. Current use of oral corticosteroids; nonsteroidal anti-inflammatory drugs, or immunosuppressive drugs; 12. Pregnant or lactating females.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue scale (VAS) score;Infrapatellar fat pad thickness; | — |
Secondary
| Measure | Time frame |
|---|---|
| WOMAC;Knee Injury and Osteoarthritis Outcome Score (KOOS); | — |
Countries
China
Contacts
Public ContactNing Rende
The First People's Hospital of Hefei
Outcome results
None listed