sepsis
Conditions
Interventions
Sponsors
Army Medical Center of PLA
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Sepsis patient: meet the diagnostic criteria of Sepsis-3.0, i.e., infection + Sequential Organ Failure Assessment (SOFA) score = 2 points;Aged 18-80 years;Signed the informed consent form. 2.General infection patients: Unexplained fever (body temperature >37.3°C), with positive results in clinical tests showing microbial culture positivity or viral antigen/IgM antibody detection positivity, but without multi-organ dysfunction (i.e., SOFA score <2);Aged 18-80 years;Signed the informed consent form. 3.Healthy controls: aed 18-80 years;with negative test results for infection, no history of chronic diseases, and diagnosed by the hematology department as having iron-deficiency anemia or thrombocytopenia that does not affect bone marrow hematopoiesis;Signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Sepsis patients: with concurrent malignant tumors, autoimmune diseases, or severe hematological disorders; have received immunosuppressive therapy or had a history of blood transfusion within the recent 3 months; with severe hepatic or renal dysfunction; Pregnant or lactating women. 2.General infection patients: with manifestations of sepsis or progression to sepsis(SOFA=2); with concurrent malignant tumors, autoimmune diseases, or severe hematological disorders; have received immunosuppressive therapy or had a history of blood transfusion within the recent 3 months; with severe hepatic or renal dysfunction; Pregnant or lactating women. 3.Healthy controls: with a history of infection within the recent 1 month(microbial culture positivity or viral antigen/IgM antibody detection positivity); a history of chronic diseases, ongoing use of drugs affecting the immune system, a history of blood transfusion; pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in composition, function, and gene expression of immune cells within the same population; | — |
Secondary
| Measure | Time frame |
|---|---|
| ICU stay;SOFA scores; | — |
Countries
China
Contacts
Public ContactZeng Ling
Army Medical Center of PLA
Outcome results
None listed