Primary aldosteronism
Conditions
Interventions
Gold Standard:1.The diagnostic criteria for primary aldosteronism (PA) referred to the 2024 Chinese Expert Consensus on the Diagnosis and Management of Primary Aldosteronism recommended by the Chinese
ARR normalization
or aldosterone suppression after a captopril challenge test)..
Index test:Using collected clinical parameters, first screen baseline characteristics significantly associated with aldosterone-producing adenoma for univariate analysis. Prioritize variables previous
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Diagnosis of PA: Patients confirmed to have Primary Aldosteronism by an endocrinologist according to the most recent diagnostic guidelines. 2.Age: >= 18 years. 3.Consent to Participate: Voluntarily agree to participate in the study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with other forms of secondary hypertension: Such as renal hypertension, renal artery stenosis, Cushing's syndrome, subclinical Cushing's syndrome, hyperthyroidism, hypothyroidism, pheochromocytoma and paraganglioma, congenital adrenal hyperplasia, or other causes of secondary hypertension (e.g., renal hypertension, endocrine hypertension). 2.Severe comorbidities: Such as severe hepatic or renal insufficiency, heart failure, etc. 3.Pregnancy and lactation: Pregnant or lactating women. 4.Other severe diseases: Malignancy, psychiatric disorders, or other conditions potentially affecting the study outcomes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma aldosterone concentration in upright position;Plasma renin concentration in upright position;Change value of aldosterone after postural stimulation test.;Lowest serum potassium;Change value of aldosterone after saline infusion test; Adrenal imaging ;Metabolic score;Change value of aldosterone after captopril test;eGFR;Upright Plasma Direct Renin Concentration (DRC) post-Saline Infusion Test;Upright Plasma Aldosterone Concentration (PAC) post-Saline Infusion Test;Upright Plasma Direct Renin Concentration (DRC) post-Captopril Challenge Test;Upright Plasma Aldosterone Concentration (PAC) post-Captopril Challenge Test;Adrenal Vein Sampling (AVS) Results;CXCR4 Receptor-Targeted Imaging Results;Blood Pressure Measurements at 1/3/6 Months Postoperatively; | — |
Countries
China
Contacts
Public ContactChen Tao
West China Hospital of Sichuan University
Outcome results
None listed