Intraoperative hypotension
Conditions
Interventions
Control group:Premedication:
Butorphanol 0.5 mg, penehyclidine 5 µg/kg, and dexamethasone 5–8 mg were administered 20 min before induction.
Control Group (Standard Anesthesia):
Induction:
Propofol (1.
Intervention Protocol:Premedication:
Administer butorphanol 0.5 mg, penehyclidine 5 µg/kg, and dexamethasone 5–8 mg 20 minutes before induction.
Experimental Group:
Induction:
Esketamine (0.2 mg/kg) ?
Sponsors
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for elective ambulatory hysteroscopic surgery with ASA physical status I-II; 2. Aged 18 to 60 years (inclusive); 3. Voluntarily signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with neuropsychiatric disorders or inability to cooperate; 2. Poorly controlled or untreated hypertension (preoperative SBP/DBP >180/100 mmHg); 3. Untreated or inadequately treated hyperthyroidism; 4. History of preoperative opioid abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypotension during anesthesia induction period; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of hypotensive episodes during anesthesia maintenance phase;Quality of Recovery-15 (QoR-15) score at 24 hours postoperatively;Anxiety and Depression Scores within 24 Hours Postoperatively (HADS Score);Pain scores at rest and during activity at 2h, 6h, 12h, and 24h postoperatively;Induction time, surgical duration, anesthesia time, and recovery time; | — |
Countries
China
Contacts
Public ContactFan Dan
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Outcome results
None listed