Pain after thoracoscopic pneumonectomy
Conditions
Interventions
Group 0.1% R:The postoperative epidural self-controlled analgesic pump was formulated as 0.1% ropivacaine + saline, totaling 250 ml.
Group 0.1% R+D:The postoperative epidural self-controlled analgesia pump was formulated as 0.1% ropivacaine + 0.5 µg/kg dexmedetomidine in a total of 250 ml.
Group 0.2% R:The postoperative epidural self-controlled analgesic pump was formulated as 0.2% ropivacaine + saline, totaling 250 ml.
Group 0.2% R+D:The postoperative epidural self-controlled analgesia pump was formulated as 0.2% ropivacaine + 0.5 µg/kg dexmedetomidine in a total of 250 ml.
Sponsors
Gansu Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. patients undergoing elective thoracoscopic pneumonectomy; 2. age 18 - 65 years; 3. ASA classification ? - II; 4. BMI 18-28 kg/m^2; 5. patients or their family members were informed of the trial in detail and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1. those who are allergic to the drugs used in this study; 2. those who experience nociceptive hypersensitivity or have a history of chronic postoperative pain; 3. coagulation abnormalities or anticoagulant therapy; 4. severe cardiac disorders (e.g., heart failure, severe heart block, preexcitation syndrome, etc.); 5. severe hepatic and renal dysfunction; 6. pregnancy; 7. those who suffer from co-morbid psychiatric disorders; and 8. intraoperative switching to an open chest.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative VAS pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first postoperative press of the PCEA pump;Total number of times the patient's POD1 and POD2 pressed the PCEA pump;Supplementary analgesia;hypertension;heart rate;QoR-15 score;First time out of bed after surgery;Timing of postoperative chest drain removal;Time to first bowel movement;Post-operative hospitalization;Indicators of stress response, including blood glucose, cortisol, and epinephrine levels.;Serum indicators of inflammatory factors, including IL-6, IL-10, TNF-a.;Incidence of adverse events, including degree of nausea and vomiting, motor and sensory blockade, degree of sedation, incidence of respiratory depression, incidence of hypotension, incidence of bradycardia, incidence of pruritus, urinary retention, and pulmonary complications.; | — |
Countries
China
Contacts
Public ContactWenjun Yan
Gansu Provincial Hospital
Outcome results
None listed