Postoperative pulmonary complications of lung surgery
Conditions
Interventions
Treat:During one-lung ventilation, the inspired oxygen concentration (FiO2) was set at 0.6, and the respiratory rate was adjusted (range: 10–16 breaths per minute) to maintain arterial partial pressur
Control:During one-lung ventilation, the inspired oxygen concentration (FiO2) was set at 1.0, and the respiratory rate was adjusted (range: 10–16 breaths per minute) to maintain arterial partial press
Sponsors
Sun Yat-sen University Cancer Center
Eligibility
Sex/Gender
All
Age
19 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. ASA Grading I.~III; 2. Age 19~75 years old; 3. Patients who are scheduled to undergo elective lung surgery and whose OLV duration is expected to exceed 1 hour; 4. Patients with normal dynamic and static pulmonary function; 5. Cardiac function grade I ~ II assessed by electrocardiogram, echocardiography, etc.; 6. Those who can eat well or can eat semi-liquid; 7. No previous history of major thoracic surgery.
Exclusion criteria
Exclusion criteria: 1. Moderate or severe obstructive pulmonary disease or restrictive lung disease in preoperative pulmonary function test; 2. Carbon monoxide dispersing capacity less than 75%; 3. Patients with contraindications to the use of permissible hypercapnia (PHC): patients with pre-existing intracranial pressure or tendency to increase (such as traumatic intracranial hematoma, intracranial mass lesions, severe hypertension), patients with uncorrected hypotension or cardiac insufficiency, and patients with previous hypercapnia or metabolic acidosis; 4. Previous medical history of contralateral lung surgery; 5. Patients with serious complications such as lung infection, atelectasis, emphysema, cor pulmonale, pleurisy, etc.; 6. Patients with contraindications to the use of PEEP: intracranial hypertension, bronchopleural fistula, hypoxemic shock, right ventricular failure; 7. Severe heart failure, defined as New York College of Cardiology (NYHA) Class III or IV, cardiac arrhythmia, or atrial fibrillation; 8. Patients with severe liver, kidney, hematopoietic system and other diseases; 9. Obesity, defined as a body mass index (BMI) greater than 30 kg/m^2; 10. Pregnancy; 11. The study protocol involves drug allergies; 12. Inability to communicate effectively.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of pulmonary complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of pulmonary complications;ICU length of stay (ICU LOS);Hospital length of stay (hospital LOS);Blood Gas Analysis;Intraoperative respiratory and circulatory indicators; | — |
Countries
China
Contacts
Public ContactLonghui Cao
Sun Yat-Sen University Cancer Center
Outcome results
None listed