End-stage osteoarthritis of the knee, Rheumatoid arthritis
Conditions
Interventions
Sufentanil Group:Tolthetron 4 mg sufentanil 2ug/kg diluted to 100ml with normal saline. The parameters are set to the background infusion speed of 2ml/h, the single compression dose is 0.5ml, the lock
Oliceridine Group:Tropisetron 4 mg Oselidine 0.4 mg/kg diluted to 100 ml with normal saline. The parameters are set to the background infusion speed of 2ml/h, the single compression dose is 0.5ml, the
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 65-80 years 2.ASA physical status classification I-III 3.Scheduled for elective total knee arthroplasty under general anesthesia 4.Postoperative patient-controlled intravenous analgesia (PCIA) planned 5.Body mass index (BMI) 18-28 kg/m^2
Exclusion criteria
Exclusion criteria: 1.Presence of significant underlying diseases (e.g., cardio/cerebrovascular, respiratory, hepatic, or renal dysfunction) 2.Inability to complete pain scale assessments due to visual/auditory impairment or illiteracy 3.Pre-existing psychiatric disorders or chronic psychotropic medication use 4.Dependence on opioids or other analgesic medications 5.Contraindications to oliceridine administration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Static and dynamic pain visual analogue (VAS) scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ramsay Sedation Score;Time to first PCA demand;The total number of PCA compressions within 48 hours;Delivered PCA boluses within 48 hours;Rescue analgesia consumption;QoR-15 scores;Athens Insomnia Scale (AIS) Score;Occurrence of adverse events within 48 hours after surgery;Patient satisfaction;The length of time from the end of the operation to the discharge from the hospital; | — |
Countries
China
Contacts
Public ContactDunyi Qi
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed