Sepsis
Conditions
Interventions
CPFA treatment group:None
Sponsors
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. For patients diagnosed with sepsis, the following two conditions should be met simultaneously :a) Confirmed infection or suspected infection; b) The SOFA score (see Appendix A) increased by >=2 points compared with the baseline or IL-6>20pg/mL. 2. Age between 18 and 85(inclusive) years old; 3.Obtain the informed consent of the patient or their legal representative.
Exclusion criteria
Exclusion criteria: 1. Patients with severe active bleeding or DIC and systemic circulatory failure that is difficult to correct with medication; 2.Those who are severely allergic to blood products or drugs used during the treatment process, such as plasma and heparin; 3.Those who have mental disorders and cannot cooperate well with the treatment; 4.Those who were previously intolerant to plasma exchange or had a history of allergy to other cardiopulmonary bypass treatments; 5.Those with a history of allergy to the membrane of the plasma separator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SOFA score;IL-6; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day mortality rate;Organ function indicators: APACHE II score, blood lactate;;Inflammatory indicators: white blood cells, procalcitonin; 12 items of cytokines; vascular endothelial growth factor (VEGF), monocyte chemoattractant protein (MCP-1);;Hemodynamic indicators: mean arterial pressure, cardiac output, dosage of vasoactive drugs;;Immune function indicators: lymphocyte count, lymphocyte subsets;;ICU hospitalization days; | — |
Countries
China
Contacts
Public ContactKailiang Fan
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Outcome results
None listed