chronic cough
Conditions
Interventions
Gold Standard:bronchial provocation test, induced sputum, multichannel intraluminal impedance-pH monitoring (MII-pH)
Index test:exhaled VOCs
Sponsors
Shanghai Tongji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age> 18 years old; (2) Cough as the only or main symptom, the course of the disease > 8 weeks; (3) There was no obvious abnormality in chest CT; (4) FEV1/FVC > 70%, and the percentage of FEV1 in the predicted value >80%;
Exclusion criteria
Exclusion criteria: (1) Currently smoking or has quit smoking for less than 2 years; (2) Pregnant or breastfeeding; (3) History of acute upper respiratory tract infection within the last 8 weeks; (4) Administration of oral or inhaled corticosteroids within the last 4 weeks; (5) Suffering from severe heart failure, significant liver or kidney dysfunction, mental and cognitive impairments, hearing and communication disorders, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| exhaled VOCs; | — |
Secondary
| Measure | Time frame |
|---|---|
| Minimum inhalation concentration of capsaicin solution corresponding to induced cough >=2 times;Minimum inhalation concentration of capsaicin solution corresponding to induced cough >=5 times;EOS% in induced sputum;acid exposure time;symptom association probability; | — |
Countries
China
Contacts
Public ContactYu Li
Shanghai Tongji Hospital
Outcome results
None listed