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Effects of tDCS Targeting the M1-SMA Area Combined With Joint Mobility Training on Functional Outcomes in Patients With Chronic Ankle Instability

Effects of tDCS Targeting the M1-SMA Area Combined With Joint Mobility Training on Functional Outcomes in Patients With Chronic Ankle Instability

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500105831
Enrollment
Unknown
Registered
2025-07-11
Start date
2025-09-01
Completion date
Unknown
Last updated
2025-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic ankle instability

Interventions

Combined M1-SMA stimulation with joint range of motion exercises:Transcranial direct current stimulation followed by joint range of motion exercises
M1-targeted tDCS combined with joint range of motion exercises:Transcranial direct current stimulation followed by joint range of motion exercises
Sham tDCS combined with joint range of motion exercises:Sham stimulation followed by joint range of motion exercises

Sponsors

Beijing sport University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Age between 18-40 years old, male or female; 2. Have a clear history of ankle sprain and the most recent sprain distance = 3 months from the start of the study; 3. Chronic ankle instability on the affected side, including: (1) Subjective feeling of ankle instability; (2) At least 2 times of "soft leg" or "sprain" of the ankle joint in the past 6 months; 4. Cumberland Ankle Instability Questionnaire (CAIT) score<=24 points; 5. Normal function of daily activities and can complete the experimental requirements; 6. Subjects voluntarily participate in the study and can complete the experimental tasks on time.

Exclusion criteria

Exclusion criteria: 1. Presence of significant structural damage or disease in the ankle joint (e.g., history of ankle fracture, severe ligament tear, or osteoarthritis); 2. History of surgery involving the ankle or lower limbs; 3. Presence of other neuromuscular or neurological disorders (e.g., stroke, Parkinson’s disease); 4. Concomitant musculoskeletal injuries or abnormalities in other lower limb joints (e.g., knee or hip disorders); 5. Contraindications to transcranial direct current stimulation (tDCS), such as: (1) History or family history of epilepsy; (2) Implanted metal or electronic devices; (3) Severe psychiatric disorders or cognitive impairments; 6. Pregnant or breastfeeding women; 7. Currently participating in other rehabilitation treatments or interventions that may affect the outcomes of this study; 8. Unable or unwilling to comply with the follow-up and assessment procedures of this study.

Design outcomes

Primary

MeasureTime frame
Cumberland Ankle Instability Scale score;Foot and Ankle Ability Measure score;Y-Balance Test;

Secondary

MeasureTime frame
Gait analysis;Range of motion;Static Center of Pressure;Sensory Organization Test;

Countries

China

Contacts

Public ContactMinyue Qiang

Beijing sport University

minney957@gmail.com+86 199 3066 5205

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026