hepatic encephalopathy (HE)
Conditions
Interventions
Standard control group:Lactulose, swallow, starting dose 30ml, three times a day, adjusted to a maximum of 2-3 soft stools per day.
Study TREATMENT GROUPS:PEG, Swallow, starting dose 25ml, 3 times a day, adjusted to a maximum of 2-3 soft stools per day.
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. aged 18-65 years; 2. In line with the diagnosis of hepatic encephalopathy type C in the guidelines for the diagnosis and treatment of hepatic encephalopathy in cirrhosis (2024 edition); 3. Grade 1-3 HE (using HESA grading standard); 4. meet one of the conditions for increased intestinal NH3 production; 5. Informed consent from guardians.
Exclusion criteria
Exclusion criteria: 1. liver failure (TB>=170umol/L+PTA<=40%); 2. previous Tips or other portosystemic shunt; 3. The neuropsychiatric symptoms were not caused by HE; 4. Use of lactulose or compound polyethylene glycol 3350 oral solution after the onset of the disease; 5. HESA4 (at the same time: unable to open eyes voluntarily, unable to respond to calls, unable to complete simple commands); 6. lack of informed consent; 7. Refusal of informed consent; 8. having participated in this study; 9. Pregnant women and other special people.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| An improvement of 1 grade or more in HESA score after 24 hours of treatment was considered effective; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complete remission of HESA score; | — |
Countries
China
Contacts
Public ContactLi Lufeng
The First Affiliated Hospital of Army Medical University
Outcome results
None listed