Postoperative Nausea and Vomiting
Conditions
Interventions
The opioid-free anesthesia group:General anesthesia (without the use of opioid drugs)+PCEA
Normall opioid anesthesia group:General anesthesia (using opioid drugs)+PCEA
Sponsors
The Seventh Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) The participant and/or their legally authorized representative voluntarily provide written informed consent for this trial. (2) Age between 18 and 65 years, inclusive (18 = 3 points). (5) Scheduled to undergo laparoscopic surgery for gastric or colorectal tumors.
Exclusion criteria
Exclusion criteria: (1) Severe impairment of major organ functions (including cardiac, hepatic, cerebral, pulmonary, or renal systems). (2) Elevated intraocular or intracranial pressure. (3) Contraindications to neuraxial anesthesia (e.g., coagulopathy or history of thoracic spine trauma). (4) Chronic opioid use or pre-existing chronic pain disorders. (5) Known allergies or contraindications to the study medications. (6) Other conditions deemed clinically unsuitable for participation by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative nausea and vomiting (PONV) in patients 72 hours after the operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| The QoR-15 scale of the patient before the operation, 24 hours after the operation and 48 hours after the operation;Postoperative extubation time;The degree of pain experienced by the patient after the operation;The incidence of postoperative hypotension;The time for postoperative patients to resume defecation and passing gas;The incidence of postoperative skin itching;Length of hospital stay for the patient; | — |
Countries
China
Contacts
Public ContactChi Xinjin
The Seventh Affiliated Hospital, Sun Yat-sen University
Outcome results
None listed