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Prospective randomized controlled clinical study on the effect of vitamin D supplementation on Thyrotropin Receptor Antibodies (TRAb) in patients with hyperthyroidism

A prospective, randomized, controlled clinical study on the effect of vitamin D supplementation on TRAb in patients with hyperthyroidism

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500105816
Enrollment
Unknown
Registered
2025-07-11
Start date
2025-08-01
Completion date
Unknown
Last updated
2025-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Graves’ disease,GD

Interventions

Experimental group:Oral levothyroxine sodium tablets were supplemented with thyroid hormones. Vitamin D (5000 IU QOD) was also supplemented
Control group:Oral levothyroxine sodium tablets for thyroid hormone supplementation

Sponsors

Panzhihua Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. 131I treatment for GD patients. 2. After taking 131I for 1-3 months, TSH increases and/or FT4 decreases, indicating successful treatment of hyperthyroidism. 3. TRAb is higher than the reference value.

Exclusion criteria

Exclusion criteria: 1. Patients who have recently taken vitamin D (6 months prior to the study) 2. Active exophthalmos patients

Design outcomes

Primary

MeasureTime frame
Thyrotropin Receptor Antibodies;25 hydroxyvitamin D;Thyroid hormone;—

Secondary

MeasureTime frame
Blood calcium;—

Countries

China

Contacts

Public ContactWu Jie

Panzhihua Central Hospital

nmi1983wujie@163.com+86 158 8127 8886

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026