Acute ST-segment elevation myocardial infarction
Conditions
Interventions
Intervention group:20mg rhPro-UK was injected into the coronary artery
control group:10ml of normal saline was injected into the coronary artery
Sponsors
The First Hospital of Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.18-75 years old; 2.STEMI=3(TIMI blood flow grade 2-3); 5.There are indications for interventional therapy; 6.Patients and their families understand the purpose and procedures of this study, voluntarily participate in this study, sign written informed consent, and are able to follow the research plan and other protocol requirements.
Exclusion criteria
Exclusion criteria: 1.STEMI>12 h; 2.TIMI thrombosis grade <3; 3.Intra-arterial thrombolysis has restored TIMI-3 grade blood flow; 4.Cardiac arrest or shock state before interventional surgery, requiring mechanical assistance; 5.Left main trunk lesion; 6.Coronary artery bridge occlusion; 7.the criminal's blood vessels have previously suffered from infarction; 8.Occluded lesions are located in the coronary artery branches; 9.Poor image quality, unable to perform QFR, cTFC, MBG analysis; 10.Women of childbearing age who are pregnant or planning to become pregnant; 11.Life expectancy is less than one year; 12.Participate in any other drug, device or biologic clinical trial currently or expected to be conducted during the study period; 13.Severe liver or kidney dysfunction; 14.Poor compliance, unable to review and follow up on time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MACE events (all-cause death, cardiovascular death, readmission for heart failure, target vessel-related AMI, Shock) at 9 months postintervention;Bleeding with perioperative BARC >=3; | — |
Secondary
| Measure | Time frame |
|---|---|
| TIMI blood flow grade and TIMI blood flow frame count (cTFC, MBG, TMPG) immediately after interventional surgery;The proportion of STR>50% within 90min after interventional surgery;LVEF values and WMSI within 24 hours after interventional surgery;LVEF values and WMS at 3 months postintervention; | — |
Countries
China
Contacts
Public ContactZheng Zhang
The First Hospital of Lanzhou University
Outcome results
None listed