Postoperative analgesia after pulmonary resection
Conditions
Interventions
2:Sufentanil:PCIA pump100ug of Sufentanil diluted with normal saline to a total volume of 100 ml,loading dose 2 ml/hour, the lockout time is 6 minutes, and each press delivers 1 ml.
1:Oliceridine:PCIA pump 20 mg of oliceridine diluted with normal saline to a total volume of 100 ml,loading dose 2 ml/hour, the lockout time is 6 minutes, and each press delivers 1 ml.
Sponsors
the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age range from 18 to 75 years old, including critical values, regardless of gender; 2. Patients who undergo unilateral lobectomy or segmental resection under thoracoscopy under elective general anesthesia and are expected to experience moderate to severe postoperative pain; 3.American Society of Anesthesiologists (ASA) rating I-II; 4.Can understand pain intensity assessment methods; 5.The subjects understand the purpose and steps of this experiment, voluntarily participate in this experiment, and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1.Accept any clinical trials within 28 days prior to surgery; 2. Body mass index (BMI)30 kg/m^2; 3. Allergy to opioid drugs; 4.Anesthesia, adjuvant analgesia, remedial analgesics, emergency antiemetics, antibiotic allergies or contraindications used in the study; 5. History of acute and chronic bronchial asthma; 6.Diagnose or suspect sleep apnea; 7.Treatment with chronic opioid drugs; 8.Preoperative use of drugs that affect analgesic response (central nervous system) a- Adrenergic drugs, antiepileptic drugs, nerve stabilizers, antidepressants or antipsychotic drugs); 9. Abnormal liver and kidney function (total bilirubin>2 x upper limit of normal value ULN during screening, aspartate aminotransferase [AST] >= 1.5 x ULN and alanine aminotransferase [ALT] >= 1.5 x ULN; creatinine>1 x ULN); 10.Extended Q-T interval on electrocardiogram (>450ms in males and>470ms in females).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour morphine equivalent; | — |
Secondary
| Measure | Time frame |
|---|---|
| The proportion of subjects who require remedial analgesia;Time of first use of remedial analgesics;Dosage of remedial analgesics used;NRS score (0, 1, 2, 4, 6, 12, 24, 36, 48 hours at rest and exercise);The number of times the analgesic pump is pressed within 48 hours, and the patient's anal exhaust time;Satisfaction score of researchers and subjects with analgesic treatment;The proportion of subjects experiencing nausea and vomiting within 48 hours and the proportion of subjects using antiemetics;;The incidence of respiratory depression within 48 hours;The proportion of subjects with common adverse reactions within 48 hours, such as headache, dizziness, itching, drowsiness or sedation, dry mouth, etc;The proportion of subjects with postoperative liver and kidney dysfunction;Record other adverse events; | — |
Countries
China
Contacts
Public ContactChunwei Lian
Wenzhou Medical University Affiliated Second Hospital
Outcome results
None listed