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A retrospective analysis of different clinical outcomes and long-term surface antigen clearance after ALT flare in chronic HBV infection

A retrospective analysis of different clinical outcomes and long-term surface antigen clearance after ALT flare in chronic HBV infection

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500105781
Enrollment
Unknown
Registered
2025-07-10
Start date
2025-07-10
Completion date
Unknown
Last updated
2025-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic HBV infection

Interventions

ALT Flair-CHB:None
ALT Flair-ACLF:None

Sponsors

The First Affiliated Hospital of Army Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.ALT Flair-CHB group: 1. HBV infection duration exceeds half a year; 2. Serum ALT level suddenly increases by more than 5 times the ULN; 3. Serum total bilirubin is less than 10 times the ULN; 4. INR is less than 1.5; 2.ALT Flair-ACLF group: 1. HBV infection duration exceeds half a year; 2. Serum ALT level suddenly increases by more than 5 times the upper limit of normal (ULN); 3. Serum total bilirubin is greater than 10 times the ULN; 4. INR is greater than 1.5.

Exclusion criteria

Exclusion criteria: 1.Combine with severe organic diseases; 2.Combine hepatitis A, hepatitis E and hepatitis C infections; 3.Combining drug-induced liver injury;

Design outcomes

Primary

MeasureTime frame
TBIL;ALT;—

Countries

China

Contacts

Public ContactHuajie Lv

The First Affiliated Hospital of Army Medical University

1210707650@qq.com+86 23 6876 5611

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026