colorectal cancer, CRC
Conditions
Interventions
Experimental group:Patients in the intervention group were given oral Bifidobacterium and Lactobacillus triple live bacteria tablets uniformly purchased by the hospital
Control group:Usual care
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.The pathological diagnosis was colorectal cancer. No distant metastasis; 2.It is planned to perform elective radical resection of colorectal cancer; 3.Age: 18 to 80 years old; 4.Informed consent and voluntary participation in the research;
Exclusion criteria
Exclusion criteria: 1.Those who are allergic to probiotic components or have had previous intolerance; 2.those with conditions such as impaired consciousness or mental disorders, who are unable to complete the questionnaire; 3.those with concurrent other tumors; 4.those who are pregnant or breastfeeding; 5.those with organ dysfunction; 6.those with a history of intestinal surgery (except for appendectomy or cholecystectomy); 7.those who have been diagnosed with hereditary colorectal cancer high-risk diseases such as familial adenomatous polyposis (FAP) or Lynch syndrome in the past; 8.those who have undergone >= 2 intestinal polyp resections within the past year; 9.those who have taken or used antibiotics/immunosuppressants/microbial preparations within 1 month before the surgery; 10.those with other infectious diseases, autoimmune diseases, uncontrolled diabetes (HbA1c>7%) or obesity (BMI>30kg/m^2) and other metabolic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence and severity of gastrointestinal symptom clusters and intra-cluster symptoms;Quality of life of patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of exhaust and defecation;Diversity of intestinal flora;DAO?I-FABP?IL-1ß?IL-6?IL-10?TNF-a; | — |
Countries
China
Contacts
Public ContactKa Li
West China Hospital of Sichuan University
Outcome results
None listed