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Effect of a Second Forward View on the Detection Rate of Proximal Sessile Serrated Lesions in a Colonoscopy Screening Population: A Multicenter, Prospective, Randomized Controlled Trial

Effect of a Second Forward View on the Detection Rate of Proximal Sessile Serrated Lesions in a Colonoscopy Screening Population: A Multicenter, Prospective, Randomized Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500105772
Enrollment
Unknown
Registered
2025-07-10
Start date
2025-08-01
Completion date
Unknown
Last updated
2025-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sessile serrated lesion

Interventions

Standard Colonoscopy Group:none
Second Forward-View Group:After completing a standard colonoscopy and withdrawing to the splenic flexure, the colonoscope was re-advanced to the cecum for a second examination of the proximal colon. T

Sponsors

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology.
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 74 Years

Inclusion criteria

Inclusion criteria: 1.Aged 40 to 74 years; 2.Undergoing colonoscopy for the first time as part of a screening program; 3.Provided written informed consent, including signature and date; 4.Willing to comply with the study protocol and participate in the entire research process.

Exclusion criteria

Exclusion criteria: 1.Severe heart failure (Classification of NYHA heart function III or IV); 2.Recent acute myocardial infarction or unstable angina; 3.Uncontrolled hypertension; 4.Chronic kidney disease; 5.Suspected intestinal obstruction or perforation; 6.Coagulation disorders; 7.Presence of hereditary polyposis syndromes, such as familial adenomatous polyposis or Peutz-Jeghers syndrome; 8.Inflammatory bowel disease or intestinal tuberculosis; 9.Liver cirrhosis or ascites; 10.Pregnant or breastfeeding women; 11.Psychiatric disorders that impair compliance with the examination; 12.Known allergy to bowel preparation agents; 13.History of prior colonoscopy; 14.History of gastrointestinal surgery or radiotherapy; 15.Inadequate bowel preparation (BBPS score <2 in any colon segment); 16.Incomplete colonoscopy (failure to reach the cecum); 17.Failure of polyp removal, inadequate tissue sampling, or absence of pathological diagnosis; 18. Subjects with various polyposis syndromes, such as familial adenomatous polyposis or Peutz-Jeghers syndrome, etc.

Design outcomes

Primary

MeasureTime frame
proximal sessile serrated lesion detection rate;

Secondary

MeasureTime frame
proximal polyp detection rate;proximal adenoma detection rate;proximal serrated polyp detection rate;Polyp miss rate;

Countries

China

Contacts

Public ContactSong Jun

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

song111jun@126.com+86 150 7245 5526

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026