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A retrospective study comparing the efficacy of neoadjuvant chemotherapy combined with immunotherapy versus neoadjuvant chemotherapy alone for esophageal squamous cell carcinoma

A retrospective study comparing the efficacy of neoadjuvant chemotherapy combined with immunotherapy versus neoadjuvant chemotherapy alone for esophageal squamous cell carcinoma

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500105757
Enrollment
Unknown
Registered
2025-07-10
Start date
2025-07-20
Completion date
Unknown
Last updated
2025-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

esophageal squamous cell carcinoma

Interventions

The neoadjuvant chemotherapy combined with immunotherapy group:None
The neoadjuvant chemotherapy treatment group:None

Sponsors

Sun Yat-sen University Cancer Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.The age range is from 18 to 80 years old; 2.The clinical diagnosis is esophageal squamous cell carcinoma of the thoracic region (ESCC), with stage T1N1-3M0 or T2-4aN0-3M0; 3.The patients have completed neoadjuvant therapy and undergone thoracic esophagectomy; 4.The clinical data are complete and can provide comprehensive treatment information.

Exclusion criteria

Exclusion criteria: 1.Previous history of malignant tumor; 2.Incomplete neoadjuvant treatment or salvage surgery; 3.Unable to assess treatment response due to lack of examination data; 4.Missing clinical data or follow-up information.

Design outcomes

Primary

MeasureTime frame
3-year progression-free survival rate and overall survival rate;

Secondary

MeasureTime frame
The recurrence and metastasis patterns 3 years after the surgery;

Countries

China

Contacts

Public ContactFu Jianhua

Sun Yat-sen University Cancer Center

fjh@sysucc.org.cn+86 151 2929 3200

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026