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comparison of perineural dexamethasone and dexamethasone dexmedetomidine in pudendal nerve block

Randomized Comparison between Perineural Dexamethasone and Dexamethasone-Dexmedetomidine for Ultrasound-Guided Pudendal Nerve Block

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500105754
Enrollment
Unknown
Registered
2025-07-10
Start date
2025-07-20
Completion date
Unknown
Last updated
2025-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative benign prostatic hyperplasia

Interventions

Dexamethasone group:The local anesthetic was 0.3% ropivacaine 8.75ml+dexamethasone 1ml (5mg)+0.9% normal saline 0.25ml.
Dexamethasone combined with dexmedetomidine group:The local anesthetic was 0.3% ropivacaine 8.75ml+dexamethasone 1ml (5mg)+dexmedetomidine 0.25ml (25ug).

Sponsors

The Third Affiliated Hosptial of ChongQing Medical University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged 18-80 years; 2. American Society of Anesthesiologists (ASA) class 1-3; 3. Benign prostatic hyperplasia confirmed by B-ultrasound, urodynamics, and serum prostate-specific antigen; 4. Preoperative coagulation was normal, and there was no contraindication of spinal anesthesia and nerve block; 5. Transurethral enucleation of the prostate was selected; 6. No chronic pain. 7. No cognitive impairment.

Exclusion criteria

Exclusion criteria: 1. Prostate cancer; 2. Neurogenic bladder; 3. Bladder neck sclerosis or other urethral diseases; 4. Refuse intraspinal anesthesia and nerve block; 5. Allergic to local anesthetics.

Design outcomes

Primary

MeasureTime frame
Effective time of pudendal nerve;

Secondary

MeasureTime frame
the incidence of Bladder spasm 3 days after the operation.;Catheter related bladder discomfort score;Duration of sensory block;Block-related complications:;Visual analog scale scores;

Countries

China

Contacts

Public ContactYinan Deng

The Third Affiliated Hosptial of ChongQing Medical University

276431048@qq.com+86 18725906194

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026