Skin aging
Conditions
Interventions
control group:Thermage+placebo without active ingredients applied externally
Test group:Thermage+active ingredient formulation for promoting HSP47 generation through external application
Sponsors
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age greater than or equal to 35 years old, less than 65 years old, healthy population, regardless of gender, no history of serious cardiovascular, digestive, endocrine, immune, nervous system or other major diseases, no history of mental or psychological abnormalities; 2.No severe acne on the face; 3.Mild to severe mandibular sagging, with a severity difference of = 2 points between the two sides; 4.Mild to severe nasolabial folds, forehead wrinkles, or crow's feet, with a difference in severity of = 2 points on both sides; 5.Meets the indications for Thermage facial treatment and is able to tolerate discomfort during the treatment process; 6.Subjects willing to read and sign the informed consent form, and willing to sign the authorization statement for image acquisition and related information; 7.Capable of treating and collecting data according to research requirements, and cooperating with visits; 8.The subjects agreed not to significantly change their lifestyle, including diet and exercise habits, throughout the entire study process; 9.The subjects accepted to use only the skin care products provided by the sponsor throughout the entire study process, without using any other skin care products, and without undergoing any beauty treatments at the beauty salon; 10.The subjects received strict sun protection measures throughout the entire study process, such as sunglasses, hats, umbrellas, masks, etc; 11.The subjects have not received any medical beauty treatment in the past 6 months, have not participated in any clinical studies in the past 1 month, and will not undergo any medical beauty treatment or participate in any other clinical trials throughout the study period;
Exclusion criteria
Exclusion criteria: 1.Pregnant and lactating women who changed, started or stopped oral contraceptives or any hormone therapy within 1.5 months before the start of the study; 2.Individuals who have implanted pacemakers or other similar electronic devices in their bodies; 3.Patients with active skin diseases, skin infections, skin tumors, a history of obvious melasma, psoriasis, rosacea, seborrheic dermatitis, and severe psoriasis; 4.The subject is currently taking or regularly taking systemic or local corticosteroids, vasoconstrictors, antibiotics, and anti-inflammatory drugs within 2 weeks prior to the start of the study; 5.Subjects have a history of acute or chronic skin diseases, medical and/or physical diseases (such as skin cancer, diabetes, asthma, hypertension, hyperthyroidism or hypothyroidism); 6.History of allergies to drugs and cosmetics; 7.Individuals with a clear history of sun exposure, phototherapy, chemical peels, or those who cannot strictly protect themselves from the sun after treatment within one month; 8.Participants who frequently engage in outdoor activities such as sunbathing and outdoor work; 9.There are other factors that affect the observation of therapeutic efficacy;
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Self evaluation;Skin hyperspectral image;Facial capacity;Skin texture;skin color;Dermal density;Doctor rating; | — |
Primary
| Measure | Time frame |
|---|---|
| Skin elasticity; | — |
Countries
China
Contacts
Public ContactDong Jiying
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Outcome results
None listed