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Effect of hypothermia on coagulation function and inflammatory factors during laparoscopic surgery

Effect of hypothermia on coagulation function and inflammatory factors during laparoscopic surgery

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500105725
Enrollment
Unknown
Registered
2025-07-09
Start date
2025-07-11
Completion date
Unknown
Last updated
2025-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intraoperative hypothermia

Interventions

Routine body temperature group:Do not use insulation measures for routine management. When the body temperature is below 35.5 ?, use a warm air blower to prevent further decrease in patient temperatur
Target body temperature group:Use a combination of warm air blower and medical heating blanket for insulation.

Sponsors

Liaocheng People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age >= 60 years; 2. Elective laparoscopic surgery; 3. ASA grading I~III; 4. BMI 18.5~28 kg/m^2; 5. The estimated duration of the operation is >=120min;

Exclusion criteria

Exclusion criteria: 1. Abnormal body temperature preoperatively; 2. Controlled cooling is expected during surgery; 3. Before surgery, there were abnormal coagulation function, immune function, and hematologic malignant diseases; 4. History of procoagulation or anticoagulation and antiplatelet use within 2 weeks before surgery; 5. Refusal to sign informed consent; 6. Changed from laparoscopy to open surgery;

Design outcomes

Primary

MeasureTime frame
Thrombin-antithrombin III complex (TAT);

Secondary

MeasureTime frame
the amount of fluid and blood transfused; length of surgery; duration of hypothermia; Degree of hypothermia (35.9-35.0 °C; 34.9-34.0 ? ; <34.0?);Tachycardia, bradycardia, nausea and vomiting;interleukin-6 (IL-6);procalcitonin (PCT);D-Dimer;

Countries

China

Contacts

Public ContactZongwang Zhang

Liaocheng People's Hospital

zwzhang68@sina.com+86 13346256809

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026