Lumbar disc herniation, spinal canal stenosis
Conditions
Interventions
Group A:Inject 0.3mg of hydromorphone hydrochloride evenly onto the dura mater patch (3cm x 4cm) using a syringe
Group B:Inject 0.45mg of hydromorphone hydrochloride evenly onto the dura mater patch (3cm x 4cm) using a syringe
Group C:Inject 0.6mg of hydromorphone hydrochloride evenly onto the dura mater patch (3cm x 4cm) using a syringe
Sponsors
Ganzhou People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 74 Years
Inclusion criteria
Inclusion criteria: 1. Voluntarily sign the informed consent form; 2. Age 18-74 years old; 3. ASA grade I~III; 4. 1-2 segment lumbar fusion patients; 5. No history of alcoholism, no visual or hearing impairment, and able to communicate normally; 6. No mental related diseases and use of psychotropic drugs; 7. Liver and kidney functions were normal.
Exclusion criteria
Exclusion criteria: 1. Patients with poor compliance, unable to complete the study or transfer halfway; 2. Patients who are judged by the investigator as unsuitable to participate in the trial; 3. Previous spinal surgery and spinal tumor surgery; 4. History of allergy to non steroidal drugs and opioids; 5. The patients were complicated with severe organ dysfunction, blood diseases or immune system diseases; 6. Long term history of taking analgesic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure, MAP;heart rate;Postoperative recovery time;Patient ambulation time;Total length of postoperative hospitalization;First exhaust time;Patient satisfaction;Intraoperative related indicators (operation time, anesthesia time, blood loss, infusion volume, urine volume);QoR-15;Adverse reactions of patients (such as PONV, drowsiness, POCD, itching, dizziness, etc.);Total number of PCA;The amount of flurbiprofen ester used for remedial analgesia;Pittsburgh sleep quality index (PSQI);Age, gender, height, weight spo2 Preoperative heart rate, preoperative blood pressure, platelet, hemoglobin, white blood cell count, CRP;Post operative Ramsay score;IL-6;TNF-a;Cortisol; S100ß; | — |
Countries
China
Contacts
Public ContactWeibo Zhong
Ganzhou People's Hospital
Outcome results
None listed