sepsis
Conditions
Interventions
lidocaine group:The loading dose of 1 mg/kg lidocaine was injected intravenously during anesthesia induction, and then intravenous infusion was continued at a rate of 1.5 mg·kg-1·h-1 until the end of
Sponsors
Xinjiang Uygur Autonomous Region People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>= 18 years old; 2. Patients with intestinal obstruction who intend to undergo exploratory laparotomy under general anesthesia; 3. Meet the diagnostic criteria for sepsis in the 2016 International Sepsis 3.0 Guidelines [14]: For patients with infection or suspected infection, sepsis can be diagnosed when the infection-related organ failure asses (SOFA) score increases by >=2 points from baseline.
Exclusion criteria
Exclusion criteria: 1. Lidocaine intolerance, allergy to lidocaine and other local anesthetics; 2. complete heart block; 3. Pregnant and lactating women; 4. Patients with chronic kidney disease, combined with kidney tumors, urinary tract stones, hydronephrosis, tuberculosis and other kidney diseases; 5. Patients with incomplete clinical data, who or their family members refuse to participate in the trial or refuse to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of AKI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum creatinine;Urea nitrogen; | — |
Countries
China
Contacts
Public ContactLi Qingqing
People's Hospital of Xinjiang Uygur Autonomous Region
Outcome results
None listed