Intraoperative high-flow cerebrospinal fluid leakage
Conditions
Interventions
one:in situ bone flap reconstruction
two:no in situ bone flap
Sponsors
The First Affiliated Hospital, the Fourth Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 70 years. 2. Signed the informed consent form (ICF). 3. Willingness to cooperate in completing the clinical study. 4. Possession of complete medical records, clear surgical indications, completion of preoperative evaluations, and exclusion of surgical contraindications. 5. Intraoperative occurrence of high-flow CSF leakage (defined as extensive subarachnoid space exposure or ventricular/cisternal exposure, with a dural defect >=1 cm²).
Exclusion criteria
Exclusion criteria: 1. Preoperative presence of severe intracranial infection. 2. Severe psychiatric or neurological disorders impairing the ability to independently comply with postoperative management and follow-up. 3. Limited life expectancy due to other medical conditions, rendering completion of the study period unfeasible. 4. Active phase of allergic rhinitis or recent history of nasal surgery. 5. History of craniocerebral trauma or related surgeries. 6. Primary thyroid diseases causing abnormal hormone levels. 7. Malignancies in other organ systems.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cerebrospinal fluid rhinorrhea;intracranial infection;Tumor resection status; | — |
Secondary
| Measure | Time frame |
|---|---|
| time of operation;hospital stays;The rate of secondary surgery;Improvement in the quality of life of patients;Recovery of sense of smell;Change in vision;hormonal level; | — |
Countries
China
Contacts
Public ContactDakuan Gao
The First Affiliated Hospital, the Fourth Military Medical University
Outcome results
None listed