delirium
Conditions
Interventions
Study Groups:Esketamine 0.2 mg/kg dexmedetomidine 0.1 µg/kg/h
Control group:Equal amount of saline dexmedetomidine 0.1 µg/kg/h
Sponsors
Henan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age> = 60 years 2. American Society of Anesthesiologists (ASA) II.-IV 3. Elective abdominal surgery under general anesthesia 4. No central nervous system disease before surgery, non-cranial surgery
Exclusion criteria
Exclusion criteria: 1. Inability to communicate due to preoperative coma, severe dementia, language impairment or severe illness 2. Delirium at the time of admission or before surgery 3. Severe hepatic dysfunction (Child-Pugh C), severe renal insufficiency (preoperative dialysis) 4. Esketamine is contraindicated for severe intracranial hypertension, hyperthyroidism or refractory hypertension
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium 7 days postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Richmond Agitation-Sedation Scale;Richards–Campbell Sleep Questionnaire;Numerical Rating Scale;Length of stay in AICU;Length of hospital stay;Analgesic drug dosage in AICU;Adverse event review rate; | — |
Countries
China
Contacts
Public ContactSun Mingyang
Henan Provincial People's Hospital
Outcome results
None listed