Crohn's disease
Conditions
Interventions
group A:In group A, patients were treated with taVNS, sham taVNS, and taVNS in alternating cycles, with the specific regimen of 1-4 weeks of taVNS, 5-8 weeks of sham taVNS, and 9-12 weeks of taVNS
group B:Patients in group B were treated with sham taVNS for 1 cycle, and then followed by 2 consecutive cycles of taVNS therapy, with the specific regimen of 1-4 weeks of sham taVNS, starting from th
Sponsors
Yancheng TCM Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Eligible patients aged 18-60 years (18 450 is defined as severe; A CDAI score of 8 mg/L or fecal calprotectin FC > 200 µg/L is defined as disease activity.
Exclusion criteria
Exclusion criteria: 1. History of serious intestinal complications or surgery: the patient has serious complications such as intestinal perforation and intestinal obstruction, or has undergone intestinal resection surgery in the past. The patient has recently (within 6 months) undergone other major surgical treatment; 2. Heart disease or diseases that affect heart rate variability (HRV): Patients have serious cardiovascular diseases (such as heart failure, arrhythmia, etc.), which may affect HRV measurement. Patients have a pacemaker because it may interfere with taVNS; 3. History of neurological diseases or epilepsy: patients with a history of central nervous system diseases or epilepsy; 4. History of psychiatric illness: having a serious psychiatric illness (such as schizophrenia, major depression, bipolar disorder, etc.) that may interfere with the evaluation of the results of the study; 5. Pregnant or lactating females; 6. Other serious chronic diseases: patients with severe liver and kidney insufficiency, or other serious chronic diseases that are not suitable for participating in the study, such as diabetic complications, chronic obstructive pulmonary disease, etc.;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CRP;FC;CDAI score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate variability;score of Inflammatory Bowel Disease Questionnaire; | — |
Countries
China
Contacts
Public ContactXu Su
Yancheng TCM Hospital
Outcome results
None listed