Obesity
Conditions
Interventions
experimental group:Wearing a u nasal aspirator containing a mixture of 2-oxovaluric acid liquid solvent and hydrogel, the average 2-oxovaluric acid release concentration is about 1075ng/L, three times
Sponsors
Central Hospital Affiliated to Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Population Subjects: 1. People with > age = 18 years old and < = 65 years old and normal olfactory function; 2. Overweight or obesity, no family history of hereditary obesity; 3. Good compliance with the experiment; 4. The patient himself or close relatives can fully understand the informed consent form, agree to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those who have participated in any drug clinical trial within 3 months before the trial; 2. Those with chronic or active gastrointestinal diseases such as esophageal diseases, gastritis, gastric ulcers, enteritis, active gastrointestinal bleeding or gastrointestinal surgery within three years; 3. Those who have a history of cardiovascular system, endocrine system, urinary system, nervous system, respiratory system, hematology, immunology (including personal or family history of hereditary immune deficiencies), psychiatry, metabolic abnormalities, etc., and the investigator believes that it is still clinically significant; 4. Those with a history of allergies to drugs, food or other substances; 5. Those with a history of tumor, epilepsy, recurrent headache, and Mycobacterium tuberculosis infection; 6. Those who cannot tolerate venous perforation or have a history of blood sickness or needle sickness; 7. Surgical operation within 3 months before the test; or those who plan to undergo surgical procedures during the study; 8. Those who have been vaccinated within 3 months before the trial; 9. Those who have used any drug within 30 days before the test; 10. Blood donors or large blood loss within 3 months before the test (>400 mL); 11. Heavy drinkers or regular drinkers within 6 months prior to the trial, i.e., drinking more than 14 units of alcohol per week (1 unit = 360 mL of beer or 45 mL of spirits with 40% alcohol or 150 mL of wine); or those who are unwilling to stop drinking alcohol or using any alcohol-containing products during the trial; or a positive alcohol breath test result (>0.0 mg/100 mL); 12. Those who drink excessive amounts of tea, coffee and/or caffeinated beverages (more than 8 cups, 1 cup = 250 mL) per day, or those who do not agree to stop drinking tea, coffee and/or caffeinated beverages during the trial; 13. Those who have special dietary requirements, cannot comply with a unified diet, or are lactose intolerant; 14. Drug abusers or those who have used soft drugs (such as marijuana) within 3 months before the test or hard drugs (such as cocaine, phencyclidine, etc.) within 1 year before the trial; 15. Creatinine clearance 12 hours (standardized pretreatment is required); 24. Subjects may not be able to complete the study due to other reasons or have other reasons that are not suitable for participating in the trial as judged by the investigator; 25
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| weight;Infrared thermal imaging; | — |
Secondary
| Measure | Time frame |
|---|---|
| Body fat composition; | — |
Countries
China
Contacts
Public ContactYongfeng Song
Central Hospital Affiliated to Shandong First Medical University
Outcome results
None listed