Postoperative Delirium
Conditions
Interventions
Remimazolam Group (R group):In the Remimazolam group (R group), anesthesia induction was performed with intravenous administration of remimazolam at 0.3 mg/kg, sufentanil at 0.3 µg/kg, and rocuronium
Propofol Group (P group):In the Propofol group (P group), anesthesia induction was performed with intravenous injection of propofol at 1–2 mg/kg, sufentanil at 0.3 µg/kg, and rocuronium at 0.6 mg/kg.
Sponsors
Shanxi Jincheng General Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 65 years, no restriction on gender; 2.Scheduled to undergo orthopedic surgery; 3.Classified as ASA physical status I–III; 4.Preoperative Mini-Mental State Examination (MMSE) score >= 21, with no evidence of significant cognitive impairment; 5.Signed informed consent obtained, with full understanding of and compliance with the study requirements.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to remimazolam; 2. Those who need ICU management or indwelling tracheal intubation after surgery; 3. BMI>35 kg/m^2 or severe cardiopulmonary disease, liver and kidney insufficiency; 4. Presence of central nervous system disease (infectious, metabolic, degenerative, neoplastic) or severe mental disorder; 5. Have a history or current presence of delirium; 6. Severe visual or hearing impairment; 7. Dependence on alcohol or other drugs; 8. Long-term or recent use of benzodiazepines, antidepressants, or antipsychotics; 9. Active symptomatic infection or systemic inflammation (elevated leukocytes or elevated C-reactive protein).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Emergence Quality;Postoperative Sleep Quality;Postoperative Pain Score; | — |
Countries
China
Contacts
Public ContactFan Wei
Shanxi Jincheng General Hospital
Outcome results
None listed