Diabetes
Conditions
Interventions
Diabetic constipation group:None
Control group:None
Sponsors
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age over 18 years old and under 75 years old. 2. No use of antibiotics, probiotics, enemas, or drugs affecting bile acid metabolism, such as bile acid sequestrants, within the last month. 3. T2DM constipation patients must meet conditions 1 and 2, and also meet the diagnostic criteria for diabetes in the 2020 "Chinese Guidelines for the Prevention and Treatment of Type 2 Diabetes Mellitus" and the definition of constipation in the 2019 "Chinese Expert Consensus on Chronic Constipation". 4. Constipation occurred after the onset of diabetes. 5. Functional constipation patients must meet conditions 1 and 2 and also meet the diagnostic criteria for functional constipation in Rome IV. 6. Healthy control group must meet conditions 1 and 2, have no history of chronic diseases or abdominal surgeries, and have a healthy lifestyle and dietary habits.
Exclusion criteria
Exclusion criteria: 1. Patients with type 1 diabetes and those with fasting blood glucose > 16.7 mmol/L that is uncontrolled. 2. Patients with constipation before the onset of diabetes. 3. Patients with previous organic intestinal lesions (such as intestinal tuberculosis, colorectal tumors, intestinal stenosis or obstruction). 4. Patients with previous surgical history of the gastrointestinal tract, liver and gallbladder, pelvis, or spine. 5. Patients with severe cardiovascular and cerebrovascular diseases, other systemic organic diseases, such as malignant tumors, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut microbiota composition and diversity assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Composition of bile acids; | — |
Countries
China
Contacts
Public ContactLiuqin Jiang
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Outcome results
None listed