Postoperative pulmonary complications
Conditions
Interventions
Control group :Goal-directed fluid therapy
Experimental group:Low-dose norepinephrine combined with restrictive deferred hydration
Sponsors
Affiliated Cancer Hospital and institute of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1)Age >= 65 years old (2)ASA physical status classification: I to III (3)Undergoing VATS under general anesthesia with bronchial intubation, including pulmonary segmentectomy, lobectomy, sleeve resection, and pneumonectomy (4)Expected surgical duration >= 2 hours, Expected postoperative hospital stay >= 2 days (5)With good cardiopulmonary function and no obvious surgical contraindications (6)Body mass index (BMI) >= 18 kg/m^2 and <= 30 kg/m^2 (7)Voluntarily participation and signed the informed consent
Exclusion criteria
Exclusion criteria: (1)Pre-existing pulmonary diseases that affect the measurement of key observation indicators before surgery (such as acute respiratory distress syndrome (ARDS), pulmonary embolism, pleural effusion, cardiogenic pulmonary edema, pneumothorax, bronchospasm, etc.). (2)Conversion to thoracotomy (3)Allergy to any general anesthetic agents, including propofol, sufentanil, remifentanil, etc. (4)Allergy to norepinephrine (5)Patients with intracranial hypertension, glaucoma, or hyperthyroidism (6)Patients with poor general condition, combined with a history of severe cardiovascular, respiratory, hepatorenal, central nervous system diseases, or extensive tumor metastasis, and with a life expectancy potentially less than 3 months (7)History of dementia, psychiatric disorders, or other neurological diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative pulmonary complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incident acute kidney injury (AKI);Incident dialysising;15-item Quality of Recovery (QoR-15) scale score;Length of Stay;Unplanned admission to intensive care unit (ICU);Creatinine,lactate levels; | — |
Countries
China
Contacts
Public ContactYao Yonghua
Affiliated Cancer Hospital and institute of Guangzhou Medical University
Outcome results
None listed