Recurrent respiratory tract infections
Conditions
Interventions
Control group:The control group did not use Saccharomyces boulardii and only received conventional treatment.
Intervention Group:The intervention group took Saccharomyces boulardii
Sponsors
Children's Hospital,Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
2 Years to 7 Years
Inclusion criteria
Inclusion criteria: 1.Children aged 2-7 years (greater than 2 years old, less than or equal to 7 years old); 2.Meet the criteria for recurrent respiratory tract infection, see (Chinese Medical Association Pediatrics Branch Respiratory Group. Chinese Journal of Pediatrics. 2008, 46(2): 108-110); 3.Sign the informed consent form and be willing to cooperate in follow-up and biological sample collection;
Exclusion criteria
Exclusion criteria: 1.Patients with clearly diagnosed primary or secondary immunodeficiency; 2.Patients with combined malformation or severe chronic systemic diseases (such as congenital heart disease, chronic renal insufficiency, pulmonary dysplasia, etc.); 3.Patients with diseases that require hormones, antibiotics, etc. (including but not limited to asthma, bacterial infections, etc.); 4.Combined respiratory foreign body; 5.Receiving immunopotentiators or probiotics or using antibiotics within 4 weeks before the study; 6.Those with a history of allergy to Saccharomyces boulardii preparations; 7.Family members cannot guarantee compliance or cannot complete follow-up;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of antibiotics used;PedsQL quality of life score;Annual number of respiratory infections; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse event rates and serious adverse events (SAEs);Differential expression of immune pathway genes;Changes in lipid metabolism profile;Changes in immune-related factors;Diversity and structural changes of intestinal flora;score of Gastrointestinal Symptom Rating Scale; | — |
Countries
China
Contacts
Public ContactYan Li
Children's Hospital,Zhejiang University School of Medicine
Outcome results
None listed