Colorectal Tumor
Conditions
Interventions
Sufentanil Group ( S):Postoperative Patient-Controlled Intravenous Analgesia (PCIA) with Sufentanil
Tegileridine Fumarate Group (F):Postoperative Patient-Controlled Intravenous Analgesia (PCIA) with Tegileridine Fumarate
Sponsors
The First People’s Hospital of Lianyungang
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients scheduled to undergo elective laparoscopic colorectal cancer surgery under general anesthesia, with an anticipated operative duration of 1-4 hours; 2. Aged >=65 years, regardless of gender; 3. Body mass index (BMI) 18-30 kg/m²; 4. American Society of Anesthesiologists (ASA) physical status classification of I-III; 5. Intended use of patient-controlled intravenous analgesia (PCIA) postoperatively; 6. Voluntarily participating in the study and providing signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Inability to comprehend the verbal pain rating scale and patient-controlled analgesia (PCA); 2. Known history of allergy to any component of the investigational drug, or hypersensitivity/contraindications to the anesthesia or analgesic agents used in the study; 3. Intellectual disability, language/communication barriers, or psychiatric disorders; 4. Concomitant severe dysfunction of the heart, brain, kidney, lung, or liver, or presence of other malignant tumors; 5. Patients who declined to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| I-FEED score at POD3; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative complications;Postoperative pain score;First occurrence time of postoperative rescue analgesia, category of medications, dosage;Time of first postoperative flatus?Time of first defecation?Time of first oral feeding;Incidence of delirium;Serum levels of gastrin, vasoactive intestinal peptide (VIP), tumor necrosis factor-a (TNF-a), and intestinal fatty acid-binding protein (I-FABP) at: Baseline (T0) ?POD 1?POD3;Total PCA attempts and successful deliveries within 48 hours postoperatively;Postoperative gastrointestinal function score (I-FEED);Hospitalization costs and length of stay; | — |
Countries
China
Contacts
Public ContactFeng Jiying
The First People’s Hospital of Lianyungang
Outcome results
None listed