Effect of Perioperative Continuous Infusion of Low-Dose Esketamine on Postoperative Depressive Symptoms in Patients Undergoing Lumbar Surgery: A Prospective Randomized Controlled Trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500105637

Enrollment

Unknown

Registered

2025-07-08

Start date

2025-07-10

Completion date

Unknown

Last updated

2025-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative depressive

Interventions

esketamine group :continuous intraoperative infusion of esketamine at 0.2 mg/kg/h, followed by a 48-hour postoperative analgesia pump(1mg/kg) containing esketamine.

control group:in the control group did not receive esketamine during surgery or in the analgesia pump

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Patients undergoing elective spinal canal decompression, intervertebral fusion, and rod-screw internal fixation under general anesthesia 2.Age 18-65 3.ASAI-IIIclass 4.BMI 17.5-26.5kg/m^2

Exclusion criteria

Exclusion criteria: 1.History of preoperative opioid abuse or alcoholism 2.pregnancy 3.allergy to esketamine or anesthetic agents 4.patients with prior lumbar reoperation 5.use or non-use of intravenous patient-controlled analgesia (PCA) pumps 6.inability to communicate or cooperate due to language, intellectual, or psychiatric disorders 7.physical disabilities 8.preoperative severe hepatic or renal dysfunction (serum creatinine >2.0 mg/dL) 9.unstable angina 10.history of cerebral hemorrhage, intracranial hypertension, or glaucoma 11.untreated or poorly controlled hypertension (systolic blood pressure >= 180 mmHg or diastolic blood pressure >= 100 mmHg).

Design outcomes

Primary

Measure	Time frame
90-day postoperative Hamilton Depression Rating Scale (HAMD) score;	—

Secondary

Measure	Time frame
preoperative BPI scores.;preoperative Hamilton Depression Rating Scale (HAMD) score;preoperative ODI scores;Serum BDNF concentrations at baseline (preoperative) ;5-HT concentrations at baseline (preoperative) ;postoperative 30 days BPI scores.;postoperative 45 days BPI scores.;postoperative 60 days BPI scores.;postoperative 90 days BPI scores.;postoperative 3 days Hamilton Depression Rating Scale (HAMD) score;postoperative 14 days Hamilton Depression Rating Scale (HAMD) score;postoperative 30 days Hamilton Depression Rating Scale (HAMD) score;postoperative 45 days Hamilton Depression Rating Scale (HAMD) score;postoperative 60 days Hamilton Depression Rating Scale (HAMD) score;postoperative 30 days ODI scores;postoperative 45 days ODI scores;postoperative 60 days ODI scores;postoperative 90 days ODI scores;Serum BDNF concentrations at POD 3;5-HT concentrations at POD 3;	—

Measure

Time frame

preoperative BPI scores.;preoperative Hamilton Depression Rating Scale (HAMD) score;preoperative ODI scores;Serum BDNF concentrations at baseline (preoperative) ;5-HT concentrations at baseline (preoperative) ;postoperative 30 days BPI scores.;postoperative 45 days BPI scores.;postoperative 60 days BPI scores.;postoperative 90 days BPI scores.;postoperative 3 days Hamilton Depression Rating Scale (HAMD) score;postoperative 14 days Hamilton Depression Rating Scale (HAMD) score;postoperative 30 days Hamilton Depression Rating Scale (HAMD) score;postoperative 45 days Hamilton Depression Rating Scale (HAMD) score;postoperative 60 days Hamilton Depression Rating Scale (HAMD) score;postoperative 30 days ODI scores;postoperative 45 days ODI scores;postoperative 60 days ODI scores;postoperative 90 days ODI scores;Serum BDNF concentrations at POD 3;5-HT concentrations at POD 3;

—

Countries

China

Contacts

Public ContactLi Na

920th Hospital of Joint Logistics Support Force

lina@kmmu.edu.cn+86 186 8700 0606

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026