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Multi omics analysis based on pathological genomics reveals heterogeneity phenotype and its correlation within tumors

Multi omics analysis based on pathological genomics reveals heterogeneity phenotype and its correlation within tumors

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500105628
Enrollment
Unknown
Registered
2025-07-08
Start date
2025-07-08
Completion date
Unknown
Last updated
2025-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast cancer

Interventions

Index test:System for integrating digital slices and clinical information

Sponsors

Yantai Yuhuangding Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. the patients were biopsy-confirmed breast cancer and defined as locally advanced breast cancer; 2. NAC followed by surgery; 3. treatment response confirmed by experienced pathologists after surgery; 4. WSIs of biopsy were available;

Exclusion criteria

Exclusion criteria: 1. history of chemotherapy, surgery or malignancy prior to NAC; 2. the patients received non-standard treatment or did not complete the NAC regimen; 3. no surgery was performed or the results of postoperative pathology were incomplete; 4. lack of clinicopathological information and WSIs for analysis requirements; 5. insufficient quality of WSIs.

Design outcomes

Primary

MeasureTime frame
P value;Cohen's Kappa Coefficient;C-index;Kaplan-Meier;Sensitivity;Specificity;

Countries

China

Contacts

Public ContactNing Mao

Yantai Yuhuangding Hospital

maoning@pku.edu.cn+86 131 0535 1972

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026