Asymptomatic intracranial atherosclerosis
Conditions
Interventions
Observation group:None
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Asymptomatic intracranial atherosclerosis patients: (1) Age 30-80 years; (2) TCD-proven intracranial artery stenosis with atherosclerosis as clinically considered; (3) No history of stroke or transient ischemic attack; (4) The temporal window has good sound permeability; (5) Sign the informed consent form. 2. Patients with asymptomatic severe stenosis: (1) Age 30-80 years; (2) Willis circumferential intracranial atherosclerotic stenosis (>70% or occlusion), confirmed by MRA or CTA; (3) No history of stroke or transient ischemic attack; (4) Good acoustic transmission of temporal window; (5) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Clinically confirmed non atherosclerosis related intracranial artery stenosis; 2.Diagnosed with neurodegenerative diseases such as Alzheimer's disease, Lewy body dementia, frontotemporal lobe degeneration, Parkinson's disease, and cognitive decline; 3.Severe neurological deficits prevent patients from living independently and are expected to be unable to complete follow-up plans; Or merge other diseases that may affect the judgment and follow-up of endpoint events, such as severe heart, lung, liver, kidney, endocrine diseases, etc; 4.Extracranial neck vascular stenosis>50%; 5.Relative/absolute contraindications related to the safety of magnetic resonance imaging (such as in vivo metal, claustrophobia, etc.); 6.Poor sound transmission through the temporal window; 7.Refusal to sign informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stroke; | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurrence and progression of cognitive impairment;Myocardial infarction;Death (vascular and non-vascular), myocardial infarction, occurrence and progression of cognitive impairment, deterioration of functional status (mRS = 2 points);Deterioration of functional status (mRS >= 2 points); | — |
Countries
China
Contacts
Public ContactXing Yingqi
Xuanwu Hospital Capital Medical University
Outcome results
None listed